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(ii) Thickening of the capillary basement membrane can be reduced

And the proportion of participants in randomized controlled trials (RCTs) who achieve clinically meaningful improvement compared with placebo varies from a high of about 15% to a low of about 10%

FOXO4-DRI Safety and Side Effects: What the Evidence Shows (2026) In the published mouse studies, FOXO4-DRI caused no reported side effects: treated animals kept their weight, blood counts, and organ markers while senescent cells were cleared, and the peptide spared healthy cells in culture