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Age and Race Kidney function declines with age

Elective surgery has also long been used as a paradigm of the stress response in humans (188-190): the magnitude of cortisol rise correlates positively with the severity of surgery (191)

Preservation of Mitochondrial DNA (mtDNA):mtDNA lacks protective histones and is located near the ROS-generating inner mitochondrial membrane, making it highly susceptible to oxidative damage