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Levels of MDA in the PBMCs were measured 4 h post- initial treatment application between the GSH-CD arm (n = 12) and the placebo arm (n = 12)

Hard exercise or muscle overuse increases reactive oxygen species (ROS) in muscles

ADP sensitivity can be rapidly modified by acute exercise or insulin treatment within 1 h, which suggests that regulation is likely at the post-translational rather than transcriptional or translational levels, although the exact mechanism is still not understood [8, 9]

Moreover, MDM2 inhibitors like Nutlin-3 and its derivatives (Idasanutlin/RG7388) have commenced clinical studies for solid tumors and hematological malignancies

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