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Brocchi, A

The BBB is composed of capillary endothelial cells, an intact basement membrane, and glial membranes surrounding astrocyte foot plates and is a barrier between the walls of brain capillaries and plasma to brain cells formed by glial cells

Youve done the right things, swapped sugar for healthy smoothies, hit the gym thrice a week, and even tried meditation apps

Although several antibody-based brain delivery techniques have been developed and evaluated in preclinical and clinical studies, including antibody engineering via chemical modifications 24 , none of them have actually been allowed for the widespread use of the delivery of monoclonal antibodies targeting GBM 25 , due to their low loading capacity which hampered binding affinity and potential immunogenicity 26

doi: 10.1016/j.jprot.2012.05.022 15 GreenbergJ