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doi: 10.1016/j.seizure.2013.04.015

Li J, Zhang A, Wu F, Wang X (2022) Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects

10.1016/j.dsx.2020.05.044 27 GorgogietasV.RajaeiB.HeeyoungC.SantacreuB

Life Sci (2021) 277:119607

This bidirectional relationship is clinically significant as anxiety and depression exacerbate pain perception, leading to poorer treatment outcomes, more severe symptoms, and reduced quality of life (Roughan et al., 2021)