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Vitamin B12 injections are a common treatment for patients with a proven B12 deficiency or specific medical needs, and when administered appropriately, these injections are considered safe and effective

Acknowledgements This work was supported by the Open Program of Shenzhen Bay Laboratory (SZBL2021080601007 to S.Y.)

When combined with 5-Amino-1MQ, which inhibits NNMT (nicotinamide N-methyltransferase) to preserve NAD+ pools, the two compounds target overlapping but mechanistically distinct pathways

Available from: /pmc/articles/PMC4717884/ 279

Future research must delineate this threshold and devise strategies, such as controlled dosing, microenvironment modulation, and combination therapies, to remain within the therapeutic window