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However, certain circumstances may warrant testing including pre-existing liver or kidney conditions where monitoring organ function during therapy provides appropriate oversight, specific health concerns that might benefit from objective biomarker assessment, desire to objectively measure oxidative stress markers or glutathione status before and during therapy, and medical conditions requiring monitoring for safety reasons

DelgadoJVoltzCStainMBalkowiec-IskraEMuellerBWernspergerJet alThe European medicines agency review of luspatercept for the treatment of adult patients with transfusion-dependent anemia caused by low-risk myelodysplastic syndromes with ring sideroblasts or Beta-thalassemia

Modifications in neurotransmitter levels by modulatory pathways such as the kynurenine pathway, and also changes in accessibility and effects of SCFAs in the brain, may have an impact on BDNF activities such as neural survival and CNS development (70)