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A large number of studies have shown that the HGF/c-Met pathway is one of the most dysregulated pathways in human malignancies, which include, but are not limited to: bladder, breast, cervical, colorectal, endometrial, esophageal, gastric, head and neck, kidney, liver, lung, nasopharyngeal, ovarian, pancreatic, prostate, and thyroid cancers ( Lastly, an activating mutations of c-Met has been discovered in sporadic and inherited forms of human renal papillary carcinomas (Danilkovitch-Miagkova and Zbar, 2002)

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The FOX04 protein is modified in normal biology by post-translation activities

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