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Therapeutic strategies targeting mtDNA-driven neuroinflammation The mtDNA-driven neuroinflammation has emerged as a pivotal pathological mechanism underlying various neurodegenerative and neuroinflammatory disorders [12, 95]

(a) Flag, (b) Glutathione-S-transferase, (c) Hexa-histidine, (d) Maltose binding protein Introduction In molecular biology and biochemistry, protein purification is a crucial process for isolating a specific protein from a complex mixture

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Results: We identified a significant reduction in hippocampal N-acetylaspartate (NAA, -13%, p=0.0001) and increased myoinositol (mI, +9%, p=0.02) in RRMS patients, before starting DMF, compared to HCs

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