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10.1007/s42114-025-01292-3 87 ZhengS.LiM.XuW.ZhangJ.LiG.XiaoH.et al (2024)

14 Transcriptional profiling also revealed that aged MuSCs acquire intrinsic defects in self-renewal capacity, linked to dysregulated p38/ mitogen-activated protein kinase (MAPK) signaling and impaired fibroblast growth factor receptor 1 (FGFR1) activity, changes that are not rescued by a young environment

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Oral NR supplementation in aged participants elevates the muscle NAD + metabolome, ameliorates metabolic dysfunction, depresses levels of circulating inflammatory cytokines and increases the anti-inflammatory molecule adiponectin in aged human

These medicines include certain heartburn medications, proton pump inhibitors, diabetes medications (such as Metaformin), and H2 blockers