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JAMA 325(6):568578 Yang Y, Hao C, Jiao T, Yang Z, Li H, Zhang Y, Zhang W, Doherty M, Sun C, Yang T, Li J, Wu J, Zhang M, Wang Y, Xie D, Wang T, Wang N, Huang X, Li C, Gonzalez FJ, Wei J, Xie C, Zeng C, Lei G (2025) Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling