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Studies in PD animal models have shown that simvastatin exerts significant antioxidant and neuroprotective effects against MPP-induced neurotoxicity [171]

Postmortem and imaging studies have revealed electron transport chain defects and impaired pyruvate dehydrogenase activity in ASD brains, with regional reductions in Complex I availability and non-ETC enzymes such as aconitase and PDH

This internal mechanism is far more comprehensive than topical creams, which often struggle to penetrate the deeper layers of the dermis

Studies have shown that butyrate enhances the expression of granzyme B in IL-10-producing Th1 cells, maintaining immune tolerance and preventing excessive inflammatory responses [441]

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