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There are still challenges to be addressed in the delivery of NPs, such as particle size, clearance by mucosal cilia, and degradation by proteases produced in vivo

Abbreviations AAB: Acetic acid bacteria ACE: Angiotensin-converting enzyme AIA: Adjuvant-induced arthritis BRS: Baroreflex sensitivity CAGR: Compound annual growth rate CDI: Clostridium difficile infection COVID-19: Coronavirus disease 2019 CRP: C-reactive protein EPS: Exopolysaccharide GOS: Galacto-oligosaccharides H: Hour(s) HbA1c: Haemoglobin A1c HDL: High-density lipoprotein HOMA-IR: Homeostatic Model Assessment of Insulin Resistance

H 2 O 2 , a necessary evil for cell signaling

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