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14.2.3 In the presence of advanced (Grade III or IV) hepatic encephalopathy or lack of response to steroids within 7 days, patients should be offered liver transplantation (LOE 4, Strong recommendation)

dee7-Gal4 ( drpr enhancer- Gal4 ) was kindly contributed by Marc Freeman (Vollum Institute, Oregon Health and Science University, USA), the Atg8a LDS stock by Ioannis Nezis (University of Warwick, UK), and vir-1-GFP.2.6 (vir-1-GFP) by Jean-Luc Imler (IBMC, University of Strasbourg, France)

Cisplatin is a nonspecific cytotoxic drug targeting the cell cycle by inhibiting the DNA replication process in cancer cells and damaging the structure of the cell membrane, endowing it with broad spectrum of anticancer efficacy

Persistent severe symptoms that interfere with daily activities or lead to dehydration should prompt immediate medical consultation, as medication discontinuation or alternative treatments may be necessary

This tripeptide structure is the basis for all biological activities of glutathione