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Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity

Regulation of potassium export channels by GSH is not yet proven in LAB and the mechanism for protection is suggested to be either sacrificial action of GSH which prevents rapid fall of intracellular pH or glutathionylation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) enzyme which helps to sustain glycolysis at the required level

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Among the three amino acids required to make glutathione (cysteine, glycine, and glutamic acid), cysteine is typically the limiting factor

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