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Discussion and Future Direction PTMs are an important regulator of protein level and activity with huge potential in translational and clinical research

Nat Rev Immunol (2017) 17:54558

TMA formed from dietary nutrients such as carnitine or choline is absorbed by the intestinal epithelium and subsequently oxidized to TMAO by hepatic flavin monooxygenases

The generation of NADPH, mainly through the pentose phosphate pathway, is intricately linked to the metabolic state of NAD + /NADH, underscoring the interdependence of these redox couples in maintaining cellular health [11, 12]