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Activation of this pathway should result in an increase in the reduced glutathione (GSH) levels, which further deactivates ROS to form the oxidized glutathione (GSSG) (38)

However, the endothelial damage observed in ME/CFS patients does not appear to correlate with the usual markers of endothelial dysfunction seen in cardiovascular disease such as increased levels of symmetric dimethylarginine (SDMA), asymmetric dimethylarginine (ADMA), and high-sensitivity C-reactive protein (hs-CRP), and reduced levels of arginine and homoarginine (311)

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The patients were randomly selected to receive VIC or placebo based on a computer randomization system with 1:1 allocation

Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages