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Together these investigations have highlighted the therapeutic potential of augmenting the HGF/c-Met system for the treatment of The HGF/c-Met Signaling Pathway Potentiating Angiogenesis: Angiogenesis is defined as the formation of new blood vessels from existing vascular bed, It is a prime requirement in physiological processes such as wound healing and the menstrual cycle, on the other hand, it is an essential step for multiple pathological conditions, like cancer, macular degeneration, atherosclerosis, diabetic retinopathy, neovascular glaucoma, psoriasis and rheumatoid arthritis