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While most metabolic compounds work through gut hormone (incretin) pathways, Tesofensine works through the brains neurotransmitter systems offering a fundamentally different pharmacological approach

Multiple sclerosis and vitamin B12 metabolism

Phycocyanin ameliorates radiation-induced acute intestinal toxicity by regulating the effect of the gut microbiota on the TLR4/Myd88/NF-B pathway

Spadoni T, Svegliati Baroni S, Amico D, Albani L, Moroncini G, Avvedimento EV, Gabrielli A (2015) A reactive oxygen species-mediated loop maintains increased expression of NADPH oxidases 2 and 4 in skin fibroblasts from patients with systemic sclerosis

Importantly, however, the observed protective effect of higher IGF-1 was observed upon adjustment of BMI, suggesting that it is not fully mediated by BMI as marker for fat mass