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This three year trial tested a PRAL diet vs bicarbonate supplementation in CKD patients and showed that the PRAL diet was more effective in preserving GFR and decreasing excretion of beneficial hormones (Goraya et al., 2014)

Acanthosis nigricans is a common skin condition that often signals an underlying health issue, such as insulin resistance, obesity, or hormonal imbalance

To make this point clear, a method like IDOL would be advantageous only if the original marker selection contains a significant number of false positives driven by such confounders, yet as shown here, IDOL would also require a larger training set for this advantage to become apparent

Rausch, T