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Tirzepatide Known by the brand names Mounjaro and Zepbound , tirzepatide is FDA-approved for type 2 diabetes and used off-label for weight loss

This growth signaling is largely mediated by IGF-1 and its regulatory binding partner, IGFBP-3

Both are GHRH-receptor agonists that raise endogenous GH and IGF-1, but tesamorelin has far stronger and more recent human data than sermorelin

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Sermorelin, a synthetic peptide, is widely recognized for its role in stimulating the production of human growth hormone (HGH) through the pituitary gland