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Hao, X, Li, W, Li, W, Gu, M, Wang, Z, Nakahashi, K, Antonoff, MB , Adachi, H, Zhou, S, Xu, S

The decline in cardiolipins is linked to mitochondrial dysfunction and heightened production of ROS due to lipid oxidation

303 Moreover, hepatic iron accumulation can induce the transcription expression of ACSL4 by activating the transcription factor c-Myc, and further aggravate the development of MASH through ferroptosis

Additionally, iron chelating agents, including chloroiodohydroxyquine and its derivatives, as well as antioxidants, have shown efficacy in animal models of AD, though clinical trials are yet to be conducted (27,106,116)

In one study looking at the impact of NAC on noise-induced hearing loss, taking 1,200 mg per day for 14 days led to a significant reduction of noise-induced temporary threshold shift