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The concept of disease-associated microglia (DAM) demonstrates how transcriptomic insights reshape our understanding of microglial states [126]

doi: 10.1186/s12986-018-0296-5 11

261 On the other hand, SIRT4 suppresses tumor growth by inhibiting glutamine metabolism, 262,263 and upon downregulation, it inhibits apoptosis and desensitizes cancer cells to chemotherapy