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Tatsunami R, Oba T, Takahashi K, Tampo Y (2009) Methylglyoxal causes dysfunction of thioredoxin and thioredoxin reductase in endothelial cells

One major challenge is enzymatic heterogeneity within the tumor microenvironment, which can affect prodrug activation efficiency

Editor information Editors and Affiliations Rights and permissions Copyright information 2017 Springer International Publishing AG, part of Springer Nature About this chapter Cite this chapter Kuniak, E., Kopczewski, T., Chojak-Koniewska, J