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The World Health Organization has ranked it the second most significant cause of disability worldwide (1517)

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31 In 1988, the discovery of single large-scale deletions of up to 7 kilobases in patients with mitochondrial myopathies 32 and a point mutation in the NADH dehydrogenase subunit 4 gene in families with LHON 33 underscored the importance of mtDNA mutations, heralding the beginning of the molecular era in mitochondrial research