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This approach not only induces cuproptosis but also increases PD-L1 expression, transforming cold tumors into hot tumors that respond to immunotherapy, significantly inhibiting tumor growth and activating a systemic anti-tumor immune response

2019 Jun 17;33:56

Of all detected transcripts, 33.9% (sum of models 2, 4 and 5) and 31.1% (sum of models 3, 4 and 5) were rhythmic in kidneys of control and cKOt mice, respectively (Figure 1A)

Preclinical studies have laid a foundation for understanding its regulatory potential, but the translational gap exposed by GDNF/NRTN clinical trials underscores the need for humility in assessing its clinical value

Le Henaff C, Mansouri R, Modrowski D et al (2015) Increased NF-B activity and decreased Wnt/-catenin signaling mediate reduced osteoblast differentiation and function in F508 cystic fibrosis transmembrane conductance regulator (CFTR) mice