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Specific activation of the glucocorticoid receptor and modulation of signal transduction pathways in human lens epithelial cells

This is not necessarily a negative side effect but rather an indication of accelerated cell turnover, where underlying congestion is brought to the surface as the skin rapidly sheds old cells and regenerates new ones

This combination provides significant GH elevation without appetite stimulation, cortisol elevation, or prolactin increases

Longer adaptation phase, but better tolerability

As a result, most dermatologists now consider microdermabrasion to be an outdated technique for skin lightening, preferring more advanced and targeted treatments such as chemical peels, laser therapy, or topical skincare products with proven skin lightening ingredients