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In this practice problem, we examine a conceptual synthetic pathway to MDMA starting from phenol , to review key ideas in electrophilic aromatic substitution and other functional group transformations

Our leading candidate liver LNP was 15000x more potent than its first-generation predecessor and has shown dose-dependent bioluminescence from luciferase activity

They cause oxidative stress

In summary, the patient-derived hepatocyte organoids and periportal assembloid models we present here hold the potential to initiate a new era in diverse areas of liver research, including in diagnostics, toxicology, personalized drug efficacy screening and cellular transplantation therapy