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As confounding by indication is difficulty to control in FAERS analyses, an integrative approach to ADE detection and investigation is beneficial [81, 82]

P values were determined by 2 tailed independent-samples t test, 1-way ANOVA with Bonferroni, Dunnett T3, Tukey HSD, and LSD posthoc tests, and 2-way repeated measures

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Mammalian Cells Cell culture Human embryonic kidney (HEK) cells were cultured in DMEM medium, containing 4.5 g/L glucose, 10 % FCS and 1 % penicillin/streptomycin, and cultivated at 37 C in a humidified atmosphere containing 5% CO 2