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Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3

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Abbreviations BP: Blood pressure CI: Confidence interval CIMT: Carotid intima-media thickness eGFR: Estimated glomerular filtration rate HbA1C: Hemoglobin A1c HDL: High-density lipoprotein cholesterol ICA: Internal carotid artery L-C: L-carnitine LDL-C: Low-density lipoprotein cholesterol Lp(a): Lipoprotein (a) MetS: Metabolic syndrome MI: Myocardial infarction MPH: Maximum plaque height NSAIDs: Nonsteroidal anti-inflammatory drugs SAEs: Serious adverse events TMAO: Metabolites such as trimethylamine oxidase TPA: Total plaque area TPV: Total plaque volume WC: Waist circumference References Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr, et al