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Conversin de Homocistena a metionina , ocurre en el citoplasma celular mediante la enzima metionina sintasa que requiere de la metilcobalamina como cofactor, resultando en una acumulacin de homocistena en plasma si no hay B12

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However, the compound became widely available for routine use in the treatment of B12 deficiency in the early 1950s

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