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Another study developed GelMA hydrogel microneedles loaded with FeO/MXene heterojunctions, which exhibit site-dependent ROS targeting: they scavenge extracellular ROS while releasing Fe/Fe to enhance intracellular ROS and induce bacterial ferroptosis, demonstrating potent antibacterial activity and wound-healing promotion in diabetic infected wounds [98]

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3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA

Although quiescent under normal conditions, PSCs are activated after pancreatic injury and transform into a myofibroblast-like -smooth muscle actin (SMA)-positive cell type that actively proliferates, produces extracellular matrix (ECM) and secretes growth factors (1215)