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Similarly, casomorphins, which are ingested via the consumption of milk products, have been suggested to cause similar withdrawal symptoms when removed from the diet

Barger SW, Goodwin ME, Porter MM, Beggs ML

Preclinical models demonstrate that these compounds reduce reactive oxygen species, stabilize mitochondrial membrane potential, enhance mitophagy, and activate NRF2 dependent transcription, which translates into attenuation of ASD like behaviors in VPA, propionic acid, maternal immune activation, and BTBR paradigms (Yang et al., 2020

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Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission