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Consequently, the nutritional approach must be highly nuanced, balancing the need to reduce systemic inflammation with the necessity of minimizing the dietary histamine burden

doi: 10.3390/bioengineering10080934 26

SF (28.2 mol/kg an hour after SCI induction) activation of Nrf2 post-SCI improved locomotor function and reduced inflammatory damage, neuron death, and spinal cord edema, while neurological deficits were more severe and the protective effect of SF was not observed in Nrf2 deficient mice (105)