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Adaptation should occur within this timeframe

Vitamin B12 supplements are recommended to population groups at higher risk for developing vitamin B12 deficiency: everyone (no matter what their diet) over 50 years old, people with diseases of the gastrointestinal system such as Chrohns and IBS, women on oral contraceptives and people who regularly use nitrous oxide or are alcoholics

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Data reported in reference 92 support a model in which the contraction of the CD8 + T-cell response is hardwired to occur independently of whether the host has successfully controlled the infection