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Current concerns include the risk of ongoing nicotine addiction, the introduction of harmful substances such as heavy metals and carcinogens into the lungs and the lack of data surrounding long-term usage

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Site-directed mutagenesis, overexpression and isolation of the CACT proteins The previously constructed pMW7-WTratCACT recombinant plasmid containing the wild-type (WT) CACT cDNA was used to introduce the mutations in the CACT protein [12]

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Post-hoc testing revealed reinstatement at the 5 and 10 mg/kg, but not 2.5 mg/kg cocaine doses (Tukeys HSD

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Thus, these compounds serve two functions: facilitating intra-mitochondrial transfer of long-chain fatty acids and detoxifying mitochondria by transferring acyl-carnitines back into the cytosol, where they become toxic 16,33

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