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Effects of Selenium Supplementation on the Indices of Disease Activity, Inflammation and Oxidative Stress in Patients with Rheumatoid Arthritis: a Randomized Clinical Trial

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PMID: 39406919 Cell Death Differ2023 Apr;30(4):1082-1095

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Given the apparent linkage between low absolute levels of vitamin B12 and elevated homocysteine, hypothyroidism, and the potential role of altered serotonin metabolism in depression, a study was conduction in which vitamin B12 status, as determined by MMA was compared to functional vitamin B2 deficiency as assessed using glutaric acid as well as the tryptophan metabolites Quinolinic Acid(QA) and Kynurenic Acid(KA) and the serotonin metabolite 5-Hydroxyindole-Acetic Acid (5HIAA)