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This loss of sensitivity is known as desensitization or tachyphylaxis when it occurs acutely over a few minutes, and tolerance or resistance when occurring over a period of days or weeks

This makes B12 supplementation generally safe, even at doses exceeding the recommended daily intake

Ibrahim MA, Ashour OM, Ibrahim YF, El-Bitar HI, Gomaa W, Abdel-Rahim SR

It is better absorbed and retained by most tissues

Injection-site reactions, including redness and pain, were the most reported side effect in the COVID vaccine trials, affecting more than 84% of patients who received a Pfizer shot