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Specifically, two-group comparisons used unpaired/paired two-tailed t -tests (with Welchs correction if variances differed), while multi-group comparisons used one-way or two-way ANOVA (using Welchs test for one-way when variances were unequal)

Structure-based optimization yields superior degrader ZZ2 A preliminary structureactivity relationship study of ZZ1 indicated that the ortho -chloro substituent is essential for potency, while substitution with other functional groups failed to yield more effective YPEL5-dependent BRD4 degraders (Supplementary Table 4)

doi: 10.1038/s41551-020-0549-2 73 IshiharaJIshiharaASasakiKLeeSSYWillifordJMYasuiMet al

23., ozone is dosed via titanium microporous aerator from the bottom column of contact reaction to realize the contact of gas and water in a reversal way

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