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361 Pharmacological side effects of COX-2 are related to the inhibition of prostacycline, which protects vascular endothelial cells, dilates blood vessels, and inhibits platelet aggregation and thrombosis

Their complementary mechanisms one acting primarily through growth factor upregulation and GI-cytoprotection, the other through actin polymerization and systemic cell migration make them uniquely interesting both individually and as a combined research subject

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