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3 Confirm sterility testing Good sources reference sterility and, ideally, endotoxin testing

In CD has been widely reported an increased expression of pore-forming proteins such as occludin and claudin-2, together with a decrease of pore-sealing proteins such as claudin-3 and -4 and ZO-1 (84, 262264)

NO secreted by macrophages also induces immune cell activation and promotes resistance to pathogens (Hu et al., 2021)

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