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This research is of great significance for the practical application of curcumin and other biomolecules ( Anti-microbial impacts of curcumin The natural components from plants are considerable antimicrobial agents may that can substitute the current antibiotics, which are facing increasingly evolving resistance by microorganisms (Figure 5) ( in vitro study, curcumin inhibited the growth of antibiotic-resistant Pseudomonas aeruginosa , Acinetobacter baumannii , and Klebsiella pneumoniae isolated from burn wound infections and showed synergism with meropenem ( Clostridioides difficile and Acetoanaerobium ( Clostridium ) sticklandii ] but did not affect Bacteroidetes ( Bacteroides fragilis and Prevotella bryantii ) ( Bacillus subtilis , E

however, this finding has not been supported in more recent studies that used low-dose oral contraceptives and controlled for dietary folate (215)

doi: 10.3389/fmicb.2023.1216674 30 ShiC-WChengM-YYangXLuY-YYinH-DZengYet al

doi: 10.1016/j.jff.2023.105783 166 GohRCMaharajanMKGopinathDFangCM