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As for alcohol, most medications used to treat psoriasis are rendered useless when they interact with alcohol.

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IGFs, including IGF-1 and IGF-2, are involved in cellular metabolic signaling and influence glucose and cholesterol uptake and glycogen storage (62,63)

Tsalic M, Bar-Sela G, Beny A, Visel B, Haim N (2003) Severe toxicity related to the 5-fluorouracil/leucovorin combination (the Mayo Clinic regimen): a prospective study in colorectal cancer patients