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The only SLE-specific prevention trial to date is the Study of Anti-Malarials in Incomplete Lupus Erythematosus (SMILE) (61), which was set to determine whether SLE progression can be abrogated by using hydroxychloroquine (HCQ) among patients with a positive ANA test and at least one (but not three or more) additional clinical or laboratory criterion from the 2012 Systemic Lupus Inception Collaborating Clinics (SLICC) classification criteria (181)