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Glutathione supports cellular detoxification through a process called conjugation

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian simvastatin survival study (4S)

doi: 10.1038/37551 Casjens SR, Mongodin EF, Qiu W-G, et al

Some people may have normal carnitine levels while others may have low levels caused by a genetic problem or certain condition that affects the body's ability to produce or absorb it

However, both pathways involve four or five catalytic steps, additionally requiring the participation of the key TCA intermediate -ketoglutarate, which might result in limited pathway efficiency