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A difference exists between the isatuximab and daratumumab trial designs for patients with chronic obstructive pulmonary disease (COPD) or other respiratory diseases, which are comorbidities that may affect outcomes in MM [59]

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NNMT inhibition in cell culture models has been associated with enhanced myogenic commitment, suggesting that the same NAD+/SAM preservation mechanism that restores adipocyte energy expenditure may also support muscle regeneration processes

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