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MacGregorDGHigginsMJJonesPAMaxwellWLWatsonMWGrahamDIet al

These findings highlight the importance of brain endothelial CYP1B1 in maintaining BBB integrity, as its deficiency exacerbated Mn-induced BBB disruption, increased brain Mn accumulation, and worsened dopaminergic neurodegeneration, underscoring the critical role of the endothelium in mediating Mn neurotoxicity

For children, acetaminophen dosage is based on weight, with a standard recommendation of 10-15 mg per kilogram of body weight per dose, given every 4 to 6 hours as needed