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et al., 2022) and can reduce intestinal 5-Hydroxytryptamine (5-HT) signaling by lowering tryptophan hydroxylase-1 (TPH1) expression levels, thereby alleviating visceral hypersensitivity (Zhao et al., 2020)

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Metformin Evidence: Long-term studies (including the TAME trial) show improved cardiovascular health, reduced inflammation, and lower all-cause mortality in diabetics