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Description

Sermorelin was first approved by the FDA as a medication called Geref to treat GH deficiency in children

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The earlier 12-week Phase 2a trial had shown encouraging results (2.6 kg vs 0.8 kg for placebo), but the larger, longer, better-powered trial reversed that finding

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A short 5-Amino-1MQ half life means that a single daily dose might lead to significant peaks and troughs in plasma levels, which could impact the consistency of its biological effects

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Some folks come in every week at first, then shift to every two or three weeks once their levels stabilize

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Clinicians will typically try standard prenatal vitamins or oral supplementation first, resorting to IM/IV B-complex therapy if those are inadequate or not feasible

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