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At higher concentration, MG is detrimental for the cell and the whole system as it reacts with major macromolecules including DNA, RNA 20 , proteins 21 and also inhibits cell proliferation 22

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It is particularly common in individuals with certain risk factors, including those who have undergone gastric or small intestine resections, have inflammatory bowel disease, use metformin or proton pump inhibitors, follow a vegan diet, or are older than 75 years